منابع مشابه
Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
Organophosphate-inhibited cholinesterases can be reactivated by nucleophilic compounds. Sometimes phosphylated (phosphorylated or phosphonylated) cholinesterases become progressively refractory to reactivation; this can result from different reactions. The most frequent process, termed 'aging', involves the dealkylation of an alkoxy group on the phosphyl moiety through a carbocation mechanism. ...
متن کاملLiquid-chromatographic determination of dolichols in urine.
A reversed-phase "high-performance" liquid chromatographic assay for dolichols-18, -19 and -20 in urine is described. Dolichols are extracted from urine by using C18 cartridges and are chromatographed with a mobile phase consisting of 2-propanol/methanol, the effluent being monitored at 210 nm. The useful lower limit of sensitivity for quantification is 4 pmol (5 ng) of each dolichol per 5-micr...
متن کاملAccumulation of phosphorylated alpha-synuclein in aging human brain.
Alpha-synuclein in Lewy bodies (LBs) is phosphorylated at Ser129. We raised monoclonal and polyclonal antibodies to this phosphorylation site (psyn) and examined 157 serial autopsy brains from a geriatric hospital. Anti-psyn immunoreactivity was observed in 40 of these cases (25.5%). Immunohistochemistry revealed 4 novel types of pathology: diffuse neuronal cytoplasmic staining (pre-LB); neurop...
متن کاملDolichols of the fern Matteucia struthiopteris.
Dolichols isolated from leaves of the fern Matteucia struthiopteris were present as a mixture of prenologues composed of 14 up to 20 isoprene units with Dol-16 dominating. They comprised approximately 0.004% of the fresh weight of fresh plant tissue and were accompanied by traces of polyprenols (Pren-14 up to Pren-17, Pren-16 dominating). Their structure was confirmed by electropray ionization ...
متن کاملThe Structure of Dolichols Isolated from Manduca sexta Larvae
We isolated and analyzed dolichols from fifth stadium larvae of Manduca sexta, in an effort to determine if M. sexta produces ethyl-branched dolichols. Like other lepidopterans, this animal is known to produce the ethyl-branched, homoisoprenoid juvenile hormones. However, we were unable to detect any ethyl-branched dolichol homologues. Manduca sexta larvae at this stage do contain the common eu...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2650891